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Journal of the Korean Society of Plastic and Reconstructive Surgeons 2001;28(1):37-43.
Published online January 1, 2001.
The Effect of an Artificial Dermis on Chondrogenesis from Perichondrium.
Dong Gul Kim, Dong Pill Shin, Jae Woo Park, Byung Chae Cho, Bong Soo Baik, Kyung Tae Yoon
1Department of Plastic & Reconstructive Surgery, College of Medicine, Kyungpook National University, Taegu, Korea.
2Department of Plastic & Reconstructive Surgery, College of Medicine, Pochon CHA University, Kumi CHA General Hospital.
The purpose of this study is to investigate the effect of artificial dermis(Terudermis(R)) on cartilage induction from perichondrium. A total of 24 rabbits were used and divided into control(n = 12) and experimental groups(n = 12). Each group was divided into 2 weeks(n = 6) and 4 weeks subgroups(n = 6). The dorsal skin of the rabbit ear was incised in reverse L-shape and the perichondrium was exposed. The silicone membrane from the Terudermis(R) , 1 x 1 cm sized,was removed. The Terudermis(R) was grafted on the exposed perichondrium in the experimental group. However, Terudermis(R) was not grafted in the control group. At 2 and 4 weeks after the surgery, the specimen was obtained and studied by histologic study. The results are as follows: 1. In control group at 2 weeks after surgery, the appearance of perichondrocytes and chondrocytes were not different from those of normal tissue. 2. In control group at 4 weeks after surgery, the extent of chondroblast differentiation and cartilage regeneration was insignificant compared to experimental group. 3. In experimental group at 2 weeks after surgery, we examined the active differentiation process of chondroblast beneath the perichondrium. The mean thickness of the neocartilage layer was 0.11+/-0.04 mm. 4. In experimental group at 4 weeks after surgery, there was an active regenerated new cartilage layer eneath the perichondrium, but the neocartilage layer was immature. The mean thickness of neocartilage layer was 0.33+/-0.10 mm. In conclusion, this study suggested that the grafted Terudermis(R) has an effect on chondrogenetic induction by activating the perichondrium.
Keywords: Terudermis(R); Cartilage regeneration; Chondrogenic induction
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