An experimental study on the effect of Ginkgo Biloba extract (EGb 761) on the healing process after weak crush injury.

Kang, So Ra; Lee, Dong Jin; Cha, Jin Han; Kim, Yang Woo

Original Article

Journal of the Korean Society of Plastic and Reconstructive Surgeons 2000;27(1):60-64.
Published online January 1, 2000.

An experimental study on the effect of Ginkgo Biloba extract (EGb 761) on the healing process after weak crush injury.

So Ra Kang, Dong Jin Lee, Jin Han Cha, Yang Woo Kim

Abstract

Late results of microvascular patency after crush or crush avulsion injury have been relatively poor. A key factor in the poor results may relate to the presence of damaged tissue, but the mechanism of this thrombus formation is still imcompletely understood. One current theory about the origin of thrombus after vessel trauma involves increased exposure of the subendothelial tissue to platelets that adhere and aggregate at the injury site, initiating thrombus formation. Most surgeons have usually used several anticoagulant drugs to prevent thrombosis for 2-3 weeks after trauma or microvascular repair. We thought that Ginkgo biloba extract (EGb 761), which has a number of pharmacologic actions, could promote microvasculature healing and prevent thrombosis. The femoral arteries of rats were dissected. Each group was as follows:-1. group A (n=10): intact group (not crushed vessel),2. group B (n=10); crushing injury (not EGb 761-treated group),3. group C (n=10); crushing injury (EGb 761-treated group). Group B and C underwent crush injury with the energy of 0.07J. We compared patency rate and histological examination. All arteries were patent at postoperative 14 days, and in histologic finding, group C (group with EGb 761 treatment among the crushed injury group) showed significant improvement of vascular endothelial and medial regeneration.