J Korean Soc Plast Reconstr Surg Search

CLOSE


Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(5):1014-1019.
Published online September 1, 1999.
The Effect of Deacetylation of Chitin and Chitosan on Wound Healing in Rats.
Yong Nam Cho, Sang Hun Chung, Gyeol Yoo, Sung Shin Wee, Yong Woo Cho, Sohk Won Ko
Abstract
Chitin and chitosan, polysaccharides made up of polymeric N-acetly glucosamine and D-glucosamine, are widely found in nature, forming the skeletons of crustaceans and insects, as well as the components of bacteria cell walls. Chitin and chitosan have been known to have many useful biological properties such as biocompatibility, biodegradability, antimicrobial activity, and wound healing. There properties have been known to be different depending on the degree of deacetylation of chitin, but it has not yet been fully evaluated. The purpose of this study was to evaluate the wound healing effect by the degree of deacetylation. Full-thickness skin incision was made on the backs of Sprague-Dawley rats. Three concentrations of powder, comprising 90% chitin, 50% chitin and 10% chitin, were separately embedded in the wounds of 3 rat groups. The wound-breaking strength and the collagen-hydroxyproline content of the skin at the wound sites were measured and histological examination was performed at postoperative 3, 7, and 10 days. The 50% chitin group had the highest tensile strenght of all groups. But the 50% chitin and 90% chitin groups had the lowest collagen hydroxyproline levels among all groups. The wounds treated with 50% chitin powder were completely reepithelialized and granulation tissue in the wound was observed 7 days after initial wounding. The arrangement of collagen fibers in the skin was ordered and similar to normal skin The 50% chitin powder is considered to be the most efficient wound healing accelerator among different concentrations of chitin powder.
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 1,270 View
  • 0 Download

The Effect of Melatonin on the Random Flap Survival in the Rat.2008 November;35(6)

Effect of Verapamil on Scar Formation in Early Wound Scarring of the Rabbit Ear.2009 January;36(1)

Optimal Concentration of Thrombin to Activate Platelet for Wound Healing.2009 January;36(1)

The Effect of Topical Application of Heparin with Microneedling on Skin Flap Survival.2009 May;36(3)

The Effects of Simvastatin on Bone Healing in Mandible Fractured Rats.2009 September;36(5)



ABOUT
ARTICLE & SPECIALITY
Article category

Browse all articles >

Speciality

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-2003, Lotte Castle President, 109, Mapodaero, Mapo-gu, Seoul 04146, Korea
E-mail: apsedit@gmail.com                

Copyright © 2024 by Korean Society of Plastic and Reconstructive Surgeons.

Developed in M2PI

Close layer
prev next