A Study of Genetic Inheritance of Bromidrosis.

Chu, Han Ho; Seo, Young Tae; Lee, Han Sol; Kim, Yeon Su; Bang, Yoo Hyun

Original Article

Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(2):210-214.
Published online March 1, 1999.

A Study of Genetic Inheritance of Bromidrosis.

Han Ho Chu, Young Tae Seo, Han Sol Lee, Yeon Su Kim, Yoo Hyun Bang

Abstract

Bromidrosis is a disorder characterized by rancid body odor which influences a patient's social life and mental health. The therapeutic modalities and the mechanism of bromidrosis have been carefully studied, however, there have been few reports about the genetic inheritance of bromidrosis. We investigated the family history of 42 patients who were operated on for bromidrosis and followed up to the third generation in 10 cases. The results were as follows:

Results
of investigation which were followed up the second generation. The fathers of five patients and the mothers of 11 patients had bromidrosis in 18 male patients. The fathers of six patients and the mothers of 12 patients had bromidrosis in 24 female patients. Thirty-four patient (81.0%) among a total of 42 have a single parent with bromidrosis. Result of investigation which were followed up to the third generation Bromidrosis was occurred in 17 of 42 patients (40.5%) in the second generation, and 18 of 27 patients (66.7%) in the third generation. In one case, a father transmitted bromidrosis to his three sons, and as a result, X-linked inheritance could be ruled out Bromidrosis was not skipped in every generation of all families. We on conclude that bromidrosis is an autosomal dominant inherited disorder.