Experimental study for the difference of cartilage regeneration between uncrushed and crushed perichondrium in rabbit ear.

Chae, Jong Hoon; Jang, Hyo Jook; Hong, In Pyo; Kim, Jong Hwan

Original Article

Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(5):749-754.
Published online July 1, 1998.

Experimental study for the difference of cartilage regeneration between uncrushed and crushed perichondrium in rabbit ear.

Jong Hoon Chae, Hyo Jook Jang, In Pyo Hong, Jong Hwan Kim

Abstract

The perichondrium has neochondrogenic potential. Many authors have published their study for the cartilage regeneration from perichondrium and the clinical uses of perichondrial graft. How is the difference of thickness of the regenerated cartilage after crushing the free perichondrial graft, compare with uncrushed graft? In this study, the perichondrium was obtained from rabbit, ears, and sectioned 10x10 mm slices. The uncrushed and crushed perichondriums were grafted into subcutaneous layer of back. After the 2,4 and 8 weeks, authors obtained regenerated cartilage from both crushed and uncrushed free perichondrial graft from rabbit back, examined the survival rate and thickness by histologic study.The results are as follows: 1. The survival rate was no difference between the uncrushed perichondrium & crushed perichondrium (p>0.05). 2. The cartilage from the uncrushed perichondrium was thicker than the crushed perichondrium, at only 8 weeks(p<0.01). 3. The thickness of regenerated cartilage was similar to the cartilage of the donor site of free perichondrial graft at 4 weeks(p>0.05).