Effect of Retinoic Acid Derivatives Using Polyethylene Glycol(PEG), Polyvinyl Pyrrolidone(PVP) on Dermal Wound Healing.

Jung, Won Seok; Cha, Jin Han; Kim, Yang Woo; Kim, Han Jung

Original Article

Journal of the Korean Society of Plastic and Reconstructive Surgeons 2004;31(5):701-706.
Published online September 1, 2004.

Effect of Retinoic Acid Derivatives Using Polyethylene Glycol(PEG), Polyvinyl Pyrrolidone(PVP) on Dermal Wound Healing.

Won Seok Jung, Jin Han Cha, Yang Woo Kim, Han Jung Kim

¹Department of Plastic and Reconstructive Surgery, College of Medicine, Ewha Womens University, Korea. ywkim@ewha.ac.kr
²Cha Lee Jung Aesthetic Clinic, Seoul, Korea.

Abstract

Retinoids are compounds with pleiotropic functions, selectively targeting certain skin structures. They are vitamins which must be derived from diet because retinol(vitamin A) is not synthesized in the body, and also they are hormones with intracrine activity, because retinol is transformed into molecules that bind to nuclear receptors, exhibit their activity, and are subsequently inactivated. Enhanced healing of full-thickness skin wounds has been demonstrated in early wound healing studies. OBJECTIVE: Our purpose is to observe the chemical and histologic effects of topical retinoid derivatives(0.05%) applied directly to the dermal wound of guinea pig. METHODS: We prepared five kinds of retinoid derivative, applied each one on the wound on back of guinea pig. After 4 and 8 weeks, each wound was observed under microscope and analyzed for the amount of the collagen.
RESULTS
Among the newly developed retinoid derivatives, PVP-RA(ester form) was the most effective in wound healing of the dermal damaged guinea pig.
CONCLUSION
Retionid derivatives were effective in dermal wound healing if well prepared.

Keywords: Retinoid; Wound healing