A Patient with Xeroderma Pigmentosum Developing Radioresistant Basal Cell Epithelioma.

Son, Won Il; Byeon, Jun Hee

Case Report

Journal of the Korean Society of Plastic and Reconstructive Surgeons 2003;30(1):101-104.
Published online January 1, 2003.

A Patient with Xeroderma Pigmentosum Developing Radioresistant Basal Cell Epithelioma.

Won Il Son, Jun Hee Byeon

Department of Plastic Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea. byeon@catholic.ac.kr

Abstract

Xeroderma pigmentosum is rare autosomal recessive disease, characterized by extreme sensitivity to ultraviolet light and leading to development of multiple malignant skin tumors. Among multiple malignant skin tumors, basal cell carcinoma and squamous cell carcinoma are common. Treatments of xeroderma pigmentosum are palliative or radiation treatment, but surgical resection is necessary if xeroderma pigmentosum is transited to malignant skin tumors. We report a case of a 32-years-old female xeroderma pigmentosum patient, who developed radiation resistant basal cell carcinoma on right alar nasi. Radiaton theraphy(300cGy, fractions: 10, total dose: 3000cGy) was not effective, so surgical excision and local skin flap coverage was made and no specific wound complications occurred. During 11 months follow-up period, no evidence of recurrence was found.

Keywords: Xeroderma pigmentosum; Radiation-resistant basal cell carcinoma