Treatment of Aplasia Cuti Congenita Using Allogenic Dermal matrix and Cultured Epithelial Autograft : A Case Report.

Lee, Jin Hwa; Kim, Yong Kyu; Lee, Sang Joon

Case Report

Journal of the Korean Society of Plastic and Reconstructive Surgeons 2006;33(5):672-675.
Published online September 1, 2006.

Treatment of Aplasia Cuti Congenita Using Allogenic Dermal matrix and Cultured Epithelial Autograft : A Case Report.

Jin Hwa Lee, Yong Kyu Kim, Sang Joon Lee

Department of plastic and Reconstructive Surgery, College of Medicine, Inje University, Seoul, Korea. psinbrain@paran.com

Abstract

PURPOSE
The purpose of this study is to document the surgical methods used in infants with aplasia cutis congenita treated with allogenic dermal matrix and cultured epithelial autografts. METHODS: The large defects in both lower legs were replaced with allogenic dermal matrix to avoid the postoperative hypertrophic scar contracture and a full- thickness skin biopsy was taken from right groin area simultaneously. We sent the specimen to a commercial laboratory for culture and obtained cultured epithelial autografts(Holoderm(R)) after 2 weeks, placed it over the allogenic dermal matrix.
RESULTS
The skin-defected area were nearly epithelialized after 2 weeks and there were no significant problem on during 6 months follow-up.
CONCLUSION
The surgical method using allogenic dermal matrix and cultured epithelial autograft provided an excellent coverage of large skin defects of infant with aplasia cutis congenita.

Keywords: Aplasia cutis congenita; Cultured epithelial autograft