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Journal of the Korean Society of Plastic and Reconstructive Surgeons 2005;32(6):683-688.
Published online November 1, 2005.
The Effect of Melatonin on Biochemical Changes after Ischemia-Reperfusion Injury of Rat Skeletal Muscle.
Hye June Park, Jin Sik Burm
1Department of Plastic and Reconstructive Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Kyunggi, Korea. hjparkps@han mail.net
2Department of Plastic and Reconstructive Surgery, Ewha Womans University College of Medicine, Seoul, Korea.
Abstract
The ischemia-reperfusion injury of the skeletal muscles is caused by generation of reactive oxygen during ischemia and reperfusion. Melatonin or N-Acetyl- 5-methoxy- tryptamine is suggested to have antioxidant effects in several tissues. In present study, we examined the protective effect of melatonin in a rat hind limb ischemia-reperfusion injury. Dimethyl-sulfoxide(DMSO) was also tested for comparison. Ischemia was induced for 4 hours by vascular clamping and followed by 1 hour or 24 hours of reperfusion. Muscle injury was evaluated in 4 groups such as single laparotomy group(control), ischemia-reperfusion group, DMSO group, melatonin group. Eedema ratio and malondialdehyde(MDA) of muscle tissue and serum level of creatine kinase(CK), were measeured at the end of reperfusion. DMSO and melatonin group showed significant amelioration of edema and serum CK compared with ischemia-reperfusion group. The decreasing effect was more prominent in melatonin group. The muscle tissue MDA concentration is significantly lower in melatonin group than in ischemia-reperfusion group. The results show that melatonin prevents and improves ischemia-reperfusion injury more effectively in a rat hind limb than DMSO dose. Thus, clinically the melatonin may be used for a beneficial treatment of such injuries.
Keywords: Skeletal muscle; Ischemia-reperfusion injury; Melatonin; DMSO
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