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Journal of the Korean Society of Plastic and Reconstructive Surgeons 2010;37(5):526-530.
Published online September 1, 2010.
The Effect of Lipo-PGE1 on the Viability of Injected Adipose Tissue on Mouse Model.
Eui Sun Oh, Ji Eun Jung, Dae Hyun Lew
Institute for Human Tissue Restoration & Department of Plastic & Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea. dhlwq@yuhs.ac
Abstract
PURPOSE
With the recent recognition of the importance of soft-tissue fillers, fat grafting has been assumed an increasingly important role as both an adjunctive and a primary procedure in aesthetic and reconstructive surgery. The main problem in achieving long-term soft-tissue augmentation is partial absorption of the injected fat and hence the need for overcorrection and re-injection. The purpose of this study is to improve the viability of the injected fat by the use of Lipo-PGE1. METHODS: Human adipose tissue, obtained by suction-assisted lipectomy, was re-injected into the subcutaneous layer in the scalp of ICR mice. Lipo-PGE1 (0.5 microgram/kg) was injected intravenously in experimental group for 7 days from the operation day and saline was injected in control group. There were 5 animals in each group. The animals were euthanized 4 weeks after the procedure. Graft weight and volume were measured and histologic evaluation was performed.
RESULTS
Histologic analysis demonstrated significantly less cyst formation and less inflammatory reaction in the group treated with Lipo-PGE1. No significant difference was found between the groups regarding graft volume or the other histologic parameters investigated. Significant differences were demonstrated in microvascular density count.
CONCLUSION
Less cyst formation, less inflammation, more angiogenesis indicating improved quality of the injected fat can be obtained by the addition of Lipo-PGE1. Further studies of various dosages of Lipo-PGE1 and their long-term effect are required before these encouraging results could be applied clinically.
Keywords: Fat graft; Lipo-PGE1; Survival rate; Histology
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