The Wound Healing Effect of PDRN(polydeoxyribonucleotide) Material on Full Thickness Skin Defect in the Mouse.

Kim, Yo Han; Lee, Jong Hoon; Min, Kyung Hee; Hong, Sung Hee; Lee, Won Mi; Jun, Jin Hyun

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Original Article

Journal of the Korean Society of Plastic and Reconstructive Surgeons 2010;37(3):220-226.
Published online May 1, 2010.

The Wound Healing Effect of PDRN(polydeoxyribonucleotide) Material on Full Thickness Skin Defect in the Mouse.

Yo Han Kim, Jong Hoon Lee, Kyung Hee Min, Sung Hee Hong, Won Mi Lee, Jin Hyun Jun

¹Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea. joaljh@eulji.ac.kr
²Department of Pathology, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.
³Department of Bio-Medical Laboratory Science, College of Health Science, Eulji University, Sungnam, Korea.

Abstract

PURPOSE
Many topical agents had been used for burn or wound treatment. An awareness of topical agents on various aspects of wound healing permits the clinician to choose the most appropriate material to advantageously control the wound process and final results. Although polydeoxyribonucleotide(PDRN) was used as a tissue repair stimulating agent in a number of human diseases, such as ulcers and burns, its wound healing effects were largely unreported. We aimed to compare the wound-healing effects of PDRN and common dressing materials on full-thickness skin defect in the mouse. METHODS: Full-thickness skin defects were made on the back of mice(N=60). The mice were divided into the following 4 groups according to the dressing used for the wounds: group O(Polydeoxyribonucleotide cream), group I (Polydeoxyribonucleotide solution), group M(Medifoam(R)), and group G(dry gauze, control group). We analyzed the gross findings, wound sizes and histological findings for the groups.
RESULTS
The rate of wound size was decreased in order of group I, group O, group M and group G. The histological findings revealed that the I group showed more reepithelialization and granulation tissue formation and less inflammatory cell infiltration than the other materials. The grade score of wound healing was increased in order of group I, group O, group M and group G.
CONCLUSION
PDRN applicated wound dressings can be used for treating a full-thickness skin defect wounds. Considering its superior efficacy in comparison to the efficacies of other wound dressings, PDRN soaked gauze dressing should be preferentially used for the treatment of full-thickness skin wounds.

Keywords: Polydeoxyribonucleotide; Skin defect; Wound healing

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