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Arch Plast Surg > Volume 46(3); 2019 > Article
Archives of Plastic Surgery 2019;46(3):214-220.
DOI: https://doi.org/10.5999/aps.2018.00157    Published online May 15, 2019.
Antithrombotic effect of epigallocatechin gallate on the patency of arterial microvascular anastomoses
Murat İğde1  , Mehmet Onur Öztürk2  , Burak Yaşar1  , Mehmet Hakan Bulam3  , Hasan Murat Ergani1  , Ramazan Erkin Ünlü1 
1Department of Plastic, Aesthetic, and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey
2Department of Plastic, Aesthetic, and Reconstructive Surgery, İzmir Çiğli Training and Research Hospital, İzmir, Turkey
3Department of Plastic, Aesthetic, and Reconstructive Surgery, Ankara Keçiören Training and Research Hospital, Ankara, Turkey
Correspondence:  Burak Yaşar, Tel: +90-312-508-45-44, Fax: +90-312-311-43-40, 
Email: burakys@outlook.com.tr
Received: 19 February 2018   • Revised: 2 February 2019   • Accepted: 9 March 2019
Abstract
Background
Microvascular anastomosis patency is adversely affected by local and systemic factors. Impaired intimal recovery and endothelial mechanisms promoting thrombus formation at the anastomotic site are common etiological factors of reduced anastomosis patency. Epigallocatechin gallate (EGCG) is a catechin derivative belonging to the flavonoid subgroup and is present in green tea (Camellia sinensis). This study investigated the effects of EGCG on the structure of vessel tips used in microvascular anastomoses and evaluated its effects on thrombus formation at an anastomotic site.

Methods

Thirty-six adult male Wistar albino rats were used in the study. The right femoral artery was cut and reanastomosed. The rats were divided into two groups (18 per group) and were systemically administered either EGCG or saline. Each group were then subdivided into three groups, each with six rats. Axial histological sections were taken from segments 1 cm proximal and 1 cm distal to the microvascular anastomosis site on days 5, 10, and 14.

Results

Thrombus formation was significantly different between the EGCG and control groups on day 5 (P=0.015) but not on days 10 or 14. The mean luminal diameter was significantly greater in the EGCG group on days 5 (P=0.002), 10 (P=0.026), and 14 (P=0.002). Intimal thickening was significantly higher on days 5 (P=0.041) and 10 (P=0.02).

Conclusions

EGCG showed vasodilatory effects and led to reduced early thrombus formation after microvascular repair. Similar studies on venous anastomoses and random or axial pedunculated skin flaps would also contribute valuable findings relevant to this topic.
Keywords: Microsurgery / Thrombosis / Catechin / Oxidants / Vasodilatation
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